Categories: network comparison

Protein interaction networks contain a wealth of biological information, but their large size often hinders cross-organism comparisons. OrthoNets is a Cytoscape plugin that displays PPI networks from two organisms simultaneously, highlighting orthology relationships and aggregating several types of biomedical annotations. OrthoNets also allows PPI networks derived from experiments to be overlaid on networks extracted from public databases, supporting the identification and verification of new interactors. Any newly identified PPIs can be validated by checking whether their orthologs interact in another organism.

Authors:

• Yanqi Hao (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Anna Merkoulovitch (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• James Vlasblom (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Shuye Pu (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Andrei L. Turinsky (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Denitza Roudeva (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Brian Turner (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Jack Greenblatt (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)
• Shoshana J. Wodak (Hospital for Sick Children, Molecular Structure Program and the Dept. of Biochemistry, University of Toronto)