Multilevel Layout Plug-In applies the conventional layout algorithms within a multilevel optimization framework to better capture the hierarchical modularity of many biological networks.
Reference:
Tuikkala J, Vahamaa H, Salmela P, Nevalainen OS, Aittokallio T. A multilevel layout algorithm for visualizing physical and genetic interaction networks, with emphasis on their modular organization. BioData Mining 2012; 5(1):2. http://www.biodatamining.org/content/5/1/2/